Implementation guidance needed for PrEP risk-prediction tools

Clinician attitudes toward CDC interim pre-exposure prophylaxis (PrEP) guidance and operationalizing PrEP for adolescents.

Prior to issuing formal HIV pre-exposure prophylaxis (PrEP) clinical practice guidelines in 2014, the US Centers for Disease Control and Prevention (CDC) had released interim guidance for oral PrEP use among adults. Because oral PrEP may be used off-label for youth and may soon be indicated for minor adolescents, we examined the potential adoption of the interim guidance among clinicians who ca...

Risk Prediction Tools in Oncology.

Cancer prediction tools are widely available to clinicians, and the data retrieved from these tools can assist with patient counseling sessions on risk, prognosis, treatment, and recurrence. Current tools are able to synthesize data in a concise, unbiased, and evidence-based method, allowing patients to make better-informed decisions about their treatment options. As useful as these tools can b...

Update to Interim Guidance for Preexposure Prophylaxis (PrEP) for the Prevention of HIV Infection: PrEP for Injecting Drug Users

On June 12, 2013, the Thailand Ministry of Health and CDC published results from a randomized controlled trial of a daily oral dose of 300 mg of tenofovir disoproxil fumarate (TDF) that showed efficacy in reducing the acquisition of human immunodeficiency virus (HIV) infection among injecting drug users (IDUs) (1). Based on these findings, CDC recommends that preexposure prophylaxis (PrEP) be c...

Pharmacology – Prep Manual for Undergraduates

Assessments tools for risk prediction of cardiovascular diseases

SCIENTIFIC BACKGROUND Cardiovascular diseases have an enormous epidemiological and economic importance. For the selection of persons with increased total cardiovascular risk for individual-targeted (e. g. drug-based) prevention interventions different risk prognosis instruments (equations, point scores and table charts) were derived from studies or databases. The transferability of these progno...